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      Thrombin-Induced Vasodilation in the Hindlimb (Dog)

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          Abstract

          The objective of this study is to test the hypothesis that the vasodilation produced by intra-arterial injection of thrombin to the hindlimb of a dog may be caused by the secondary release or production of some vasodilating substance. The vasodilator response to thrombin was compared with the vasodilator response to acetylcholine, isoproterenol, histamine and serotonin before and after blockade with atropine, propranolol, phenergan or methyl-D-lysergic acid butanolamide (UML-491), respectively. Though the appropriate blocking agent blocked the vasodilator response to the respective drug, the thrombin-induced vasodilation was not blocked. These data support the hypothesis that thrombin-induced vasodilation is a response to the thrombin moiety.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1977
          1977
          18 September 2008
          : 14
          : 3
          : 129-140
          Affiliations
          Department of Physiology, University of North Carolina, Chapel Hill, N.C.
          Article
          158121 Blood Vessels 1977;14:129–140
          10.1159/000158121
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 12
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