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      ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.

      Bioorganic & Medicinal Chemistry
      Biphenyl Compounds, chemistry, metabolism, Estrogen Receptor beta, Genistein, Hydroxylation, Inhibitory Concentration 50, Ligands, Models, Molecular, Molecular Structure, Protein Conformation, Receptors, Estrogen, Structure-Activity Relationship, Substrate Specificity

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          Abstract

          The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERbeta selectivity on the order of 20-70-fold.

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