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      Multiple potential roles for B cells in atherosclerosis.

      1 ,
      Annals of medicine
      Informa UK Limited
      Atherosclerosis, immunity, lymphocytes

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          Abstract

          The development of atherosclerosis is the major etiological factor causing cardiovascular disease and constitutes a lipid-induced, chronic inflammatory and autoimmune disease of the large arteries. A long-standing view of the protective role of B cells in atherosclerosis has been challenged by recent studies using B cell depletion in animal models. Whereas complete B cell deficiency increases atherosclerosis, depletion of B2 but not B1 cells reduces atherosclerosis. This has led to a re-evaluation of the multiple potential pathways by which B cells can regulate atherosclerosis, and the apparent opposing roles of B1 and B2 cells. B cells, in addition to having the unique ability to produce antibodies, are now recognized to play a number of important roles in the immune system, including cytokine production and direct regulation of T cell responses. This review summarizes current knowledge on B cell subsets and functions, and how these could distinctly influence atherosclerosis development.

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          Author and article information

          Journal
          Ann. Med.
          Annals of medicine
          Informa UK Limited
          1365-2060
          0785-3890
          Aug 2014
          : 46
          : 5
          Affiliations
          [1 ] Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge , Cambridge , UK.
          Article
          10.3109/07853890.2014.900272
          24813455
          15c9a54f-33f0-4ba3-b6a7-da86c1b772e5
          History

          Atherosclerosis,lymphocytes,immunity
          Atherosclerosis, lymphocytes, immunity

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