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      Derivatized amino acids relevant to native peptide synthesis by chemical ligation and acyl transfer.

      The Journal of Organic Chemistry
      Acylation, Alanine, chemistry, Amino Acids, Glycine, Ligation, Models, Chemical, Molecular Structure, Peptides, chemical synthesis, Serine

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          Abstract

          Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.

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          Author and article information

          Journal
          14629143
          10.1021/jo030192r

          Chemistry
          Acylation,Alanine,chemistry,Amino Acids,Glycine,Ligation,Models, Chemical,Molecular Structure,Peptides,chemical synthesis,Serine

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