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      A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency

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      Nephron

      S. Karger AG

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          Abstract

          Plasma renin activity was measured before and after dialysis in 27 uremic patients on a chronic dialysis program. Pre-dialysis renin levels were variable; the highest value occurred in the only patient with malignant hypertension. With this exception, there was no correlation between blood pressure and renin. Renin substrate levels were normal. After dialysis, renin activity rose significantly. There is a suggestive correlation between the decrease in mean arterial pressure and the increase in renin activity during dialysis. Biopsy and autopsy specimens of four kidneys examined with the Bowie stain demonstrate some normal JG cells with granules in the severely scarred kidneys. These cells may synthesize renin at an enormous rate to maintain normal plasma levels. In addition, uremic plasma appears to be deficient of a normal inhibitor or possibly contains an accelerator of the reaction between renin and its substrate.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1970
          1970
          26 November 2008
          : 7
          : 4
          : 317-330
          Affiliations
          Departments of Internal Medicine and Pathology, Yale University School of Medicine, New Haven, CT
          Article
          179832 Nephron 1970;7:317–330
          10.1159/000179832
          4316656
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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