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Mechanisms of gene silencing by double-stranded RNA.

Nature

metabolism, chemistry, Ribonucleoproteins, genetics, RNA, Messenger, RNA, Double-Stranded, RNA Processing, Post-Transcriptional, Protein Biosynthesis, Gene Silencing, Animals

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      Abstract

      Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference. A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure. These short dsRNAs guide RNA silencing by specific and distinct mechanisms. Many components of the RNA silencing machinery still need to be identified and characterized, but a more complete understanding of the process is imminent.

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      Journal
      10.1038/nature02873
      15372041

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