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Effects of dietary magnesium on testicular histology, steroidogenesis, spermatogenesis and oxidative stress markers in adult rats.

Indian journal of experimental biology

17-Hydroxysteroid Dehydrogenases, metabolism, 3-Hydroxysteroid Dehydrogenases, Animals, Antioxidants, Diet, Enzyme-Linked Immunosorbent Assay, methods, Feeding Behavior, Female, Follicle Stimulating Hormone, Lipid Peroxidation, Luteinizing Hormone, Magnesium, pharmacology, Male, Oxidative Stress, Radioimmunoassay, Rats, Rats, Wistar, Spectrometry, Fluorescence, Spermatogenesis, drug effects, Steroids, Testis

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      Abstract

      The available information on the effect of excess dietary magnesium on male reproduction is inadequate, though consumption of hard water rich in magnesium salt is not uncommon in many geographical areas. The present study has thus been undertaken to evaluate the morphological as well as cytological and functional changes in testis of magnesium administered sexually mature male Wistar rats. Significant increase in the activities of androgenic enzymes viz. delta(5)3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase with concomitant increase in serum testosterone level, followed by progressive development in cytoarchitechture of genital organs, without any significant alteration in quantitative spermatogenesis were observed. The results were more marked in the groups treated for longer duration. The results further suggests that the changes that occurred after excessive magnesium in testis were not for the enhanced adrenocortical activities or for the generation of oxidative stress in reproductive organs, but for the direct action of excess magnesium on male gonads. Magnesium supplementation thus has an apparent beneficial effect on male gonadal system.

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