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      Nanoemulsion: a promising tool for solubility and dissolution enhancement of celecoxib.

      1 ,
      Pharmaceutical development and technology
      Informa Healthcare

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          Abstract

          The solubility and dissolution of the poorly soluble drug celecoxib (CXB) was enhanced using many techniques like nanoemulsion, solid lipid nanoparticle and solid dispersion in the present investigation. The solubility of CXB in each formulation was determined using the reported HPLC method at the wavelength of 250 nm. Dissolution studies of pure CXB and its formulations were performed using USP dissolution apparatus in distilled water. The highest solubility (228. 24 mg/mL) as well as % dissolution (99.9) of CXB was obtained with nanoemulsion technique. The results of solubility and dissolution were highly significant using the nanoemulsion technique as compared to other techniques (P < 0.01). All three formulations showed a sustained type of drug release. The best sustained type drug release was obtained with nanoemulsion. This indicated that nanoemulsion can be successfully used for sustained and controlled drug delivery of CXB. Overall these findings suggested that nanoemulsion is a promising vehicle for solubility and dissolution enhancement of CXB.

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          Author and article information

          Journal
          Pharm Dev Technol
          Pharmaceutical development and technology
          Informa Healthcare
          1097-9867
          1083-7450
          June 26 2009
          : 15
          : 1
          Affiliations
          [1 ] Department of Pharmaceutics, Faculty of Pharmacy, Al-Arab Medical University, Benghazi-5341, Libya. faiyazs@fastmail.fm
          Article
          10.3109/10837450902967954
          19552546
          16260ed1-9cc4-4fa1-aa46-877a3ce0ca3d
          History

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