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      Diminished Responsiveness of the Failing Human Myocardium to Glucagon

      , ,

      Cardiology

      S. Karger AG

      Glucagon, Isoproterenol, Paired stimulation, Congestive heart failure, Papillary muscle

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          Abstract

          Eight left ventricular papillary muscles were removed from patients at the time of mitral valve replacement (all patients functional class 3 to 4) and were studied in a myograph in vitro to determine their relative responsiveness to various inotropic agents. Results were compared with 7 dog and 9 cat papillary muscles studied under the same conditions. Maximum dp/dt of an isometric contraction at Lmax was used as an index of contractile state. The ratios of the response to 10<sup>-5</sup> M glucagon and 10<sup>-5</sup> M isuprel (G/I) and to glucagon and paired stimulation (G/PS), were used as indices of glucagon responsiveness. In the human muscles, G/I = 0.03 ± 0.01, G/PS = 0.07 ± 0.02; for the dog papillary muscles. G/I = 0.40 ± 0.08, G/PS = 0.34 ± 0.05; and for the cat papillary muscles, G/I = 0.29 ± 0.05, G/PS = 0.28 ± 0.05. Although no data is available from normal human papillary muscles, the present data suggests that the failing human myocardium has a reduced inotropic response to glucagon.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1970
          1970
          29 October 2008
          : 55
          : 4
          : 211-217
          Affiliations
          Departments of Cardiology and Cardiovascular Surgery, Cedars-Sinai Medical Center, Los Angeles, Calif.
          Article
          169284 Cardiology 1970;55:211–217
          10.1159/000169284
          5520044
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
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