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      No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.

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          Abstract

          The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, but a recent study suggested an independent involvement of another polymorphism located within the promoter -1123 nucleotides relative to the translational start site.

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          Author and article information

          Journal
          Diabetes Res. Clin. Pract.
          Diabetes research and clinical practice
          Elsevier BV
          0168-8227
          0168-8227
          May 2007
          : 76
          : 2
          Affiliations
          [1 ] University Hospital Motol, The 2nd Medical School, Charles University, Prague, Czech Republic. Ondrej.Cinek@Lfmotol.cuni.cz
          Article
          S0168-8227(06)00393-7
          10.1016/j.diabres.2006.09.009
          17000021
          1632bf86-5c6e-4667-8e8e-a497024fffe3
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