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      Agave fructans and oligofructose decrease oxidative stress in brain regions involved in learning and memory of overweight mice.

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          Abstract

          Obesity is currently a public health problem worldwide. Recently, non-reducing carbohydrates, that include β(2→1) and β(2→6) linkages in their structure, have been of particular interest in the field of obesity because they are involved in lipid metabolism. Some of these are agave fructans (AF) and oligofructose (OF). In this study, we evaluated both AF and OF on oxidative stress (OS) markers in the brain of overweight mice (OM). AF and OF decreased TBARS levels and carbonyls at different levels in hippocampus (HP), frontal cortex (FC) and cerebellum (CB) of OM. The results indicated that fructans may have anti-oxidative potential and can be used as an alternative treatment for the prevention of the consequences of this pathology.

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          Author and article information

          Journal
          Nat Prod Res
          Natural product research
          Informa UK Limited
          1478-6427
          1478-6419
          May 2019
          : 33
          : 10
          Affiliations
          [1 ] a Departamento de Veterinaria y Zootecnia , División de Ciencias de la Vida, Campus Irapuato-Salamanca, Universidad de Guanajuato , León , México.
          [2 ] b Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León , Universidad de Guanajuato , Leon de los Aldama , México.
          [3 ] c Centro de Investigación y de Estudios Avanzados del IPN , Irapuato , México.
          Article
          10.1080/14786419.2017.1423297
          29313362
          1650f6a1-ff34-4ae9-85f7-ccb9dba2c22c
          History

          Fructans,brain,overweight mice,oxidative stress,prebiotics
          Fructans, brain, overweight mice, oxidative stress, prebiotics

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