Blog
About

6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Obesity and asthma: implications for treatment.

      Current Opinion in Pulmonary Medicine

      physiology, Weight Loss, Risk Factors, Prevalence, physiopathology, epidemiology, complications, Obesity, Mice, Obese, Mice, Humans, Disease Models, Animal, drug therapy, Bronchial Hyperreactivity, therapy, etiology, Asthma, therapeutic use, Anti-Asthmatic Agents, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Epidemiological data as well as data from mouse models of asthma indicate a relationship between obesity and asthma. The purpose of this review is to evaluate recent data addressing this relationship and its biological basis, and to evaluate the implications of these data for treatment. Obesity increases the prevalence, incidence, and possibly severity of asthma, while weight loss in the obese improves asthma outcomes. Obesity also influences asthma control and the response to standard asthma therapeutics. Moreover, obese mice exhibit innate airway hyperresponsiveness and increased responses to common asthma triggers. The biological basis for the relationship between obesity and asthma may be the result of common etiologies, comorbidities, effects of obesity on lung volume, or adipokines such as tumor necrosis factor alpha, leptin, and adiponectin. Understanding the mechanistic basis for the relationship between obesity and asthma may lead to new therapeutic strategies for treatment of this susceptible population.

          Related collections

          Author and article information

          Journal
          10.1097/MCP.0b013e3280110196
          17133126

          Comments

          Comment on this article