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      Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

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          Abstract

          Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role in cancer cell growth and resistance to therapy. Most mutations occur at codons 12 and 13. In colorectal cancer, the presence of any mutant KRas amino acid substitution is a negative predictor of patient response to targeted therapy. However, in non-small cell lung cancer (NSCLC), the evidence that KRAS mutation is a predictive factor is conflicting.

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          Author and article information

          Journal
          J Natl Cancer Inst
          Journal of the National Cancer Institute
          Oxford University Press (OUP)
          1460-2105
          0027-8874
          Feb 08 2012
          : 104
          : 3
          Affiliations
          [1 ] Department of Experimental Therapeutics, The Hamon Center for Therapeutic Oncology Research and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
          Article
          djr523
          10.1093/jnci/djr523
          3274509
          22247021
          1670a897-ef95-47cf-9076-3fbf830af064
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