Newbergconcluded his well-known scientific experiment,Wrote,“A singleword has the power to influence the expression of genes that regulate physical and emotional stress”. However, could architectural space also speak?Alter the expression ofgenes?This study aimed to investigate the relationship between architecture, brain and genes. Objectives, to test the influence of architecture over brain’s “electrical-activity. And to develop, Theory of space and genes. Research-methodology,Firstly, An integrated approach for literature review. Secondly,An experimental approach. Thirdly,An integrative analysis. Findings showed a significant change of brain-electricity by change of environments. Therefore, alteration in the expression of genes.