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      Tumor-derived CD4+CD25+regulatory T cells inhibit dendritic cells function by CTLA-4.

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          Abstract

          CD4+CD25+regulatoryT cells (Tregs) play an important role in anti-tumor immune responses. Poor prognosis and declining survival rates have intimate connection with high Treg expression in cancer patients. Cytotoxic T Lymphocyte-associated protein (CTLA-4) is one of the most prominent molecules on Treg. In our previous research, we have demonstrated that HCC-derived Tregs can interfere with Dendritic cells (DCs) function and down-modulate CD80/CD86 on DCs in vitro in a cell-contact dependent way. However the mechanism of how HCC-derived Treg affect DC phenotype are not very clear. Therefore, we investigated the function of CTLA-4 in anti-tumor immune responses.

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          Author and article information

          Journal
          Pathol. Res. Pract.
          Pathology, research and practice
          Elsevier BV
          1618-0631
          0344-0338
          Mar 2017
          : 213
          : 3
          Affiliations
          [1 ] Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
          [2 ] Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, ZheJiang, China.
          [3 ] Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. Electronic address: 515359290@qq.com.
          Article
          S0344-0338(16)30236-9
          10.1016/j.prp.2016.12.008
          28214198
          16a1d762-4401-47f0-9ac0-e896b5588369
          History

          CTLA-4,Dendritic cell,CD4+CD25+regulatory T cell
          CTLA-4, Dendritic cell, CD4+CD25+regulatory T cell

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