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      Acidic Fibroblast Growth Factor (aFGF) in Developing Normal and Dystrophic (mdx) Mouse Muscles. Distribution in Degenerating and Regenerating mdx Myofibres

      , ,
      Growth Factors
      Informa UK Limited

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          Most cited references20

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          Recent developments in the cell biology of basic fibroblast growth factor

          D Rifkin (1989)
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            Hormones, growth factors, and myogenic differentiation.

            Three families of growth factors/hormones have major effects on the differentiation of skeletal muscle cells. Two (FGF and TGF-beta) are potent inhibitors, and the third (IGF) exhibits a biphasic stimulatory action (but is not inhibitory even at high concentrations). All of these affect the expression of myogenin, one of the recently discovered family of myogenesis controlling genes, and FGF and TGF-beta have been shown to inhibit the expression of MyoD1 (and probably myf-5 and herculin) as well. These agents inhibit or stimulate (respectively) all measured aspects of myogenic differentiation--fusion, expression of a set of muscle-specific genes, and attainment of a postmitotic state--in all cells that are capable of these responses, whether cell lines or primary muscle cell cultures. It now seems clear that the myogenesis controlling genes regulate the entire family of muscle-specific proteins. Therefore the demonstration that expression of these genes is controlled (both positively and negatively) by specific growth factors that are now available at high purity and in useful quantities offers the possibility of understanding myogenic differentiation at a level of molecular detail that is very exciting.
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              Conservation of the Duchenne muscular dystrophy gene in mice and humans.

              A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.
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                Author and article information

                Journal
                Growth Factors
                Growth Factors
                Informa UK Limited
                0897-7194
                1029-2292
                July 11 2009
                January 1992
                July 11 2009
                January 1992
                : 7
                : 2
                : 97-106
                Article
                10.3109/08977199209046399
                16a54c4f-e2de-40e7-8234-5154d877969b
                © 1992
                History

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