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      Anti-tumor necrosis factor-α therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis.

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          Abstract

          Rheumatoid arthritis (RA) is a systemic inflammatory condition associated with increased cardiovascular risk. This is not fully explained by traditional risk factors, but direct vascular inflammation and aortic stiffening may play a role. We hypothesized that patients with RA exhibit aortic inflammation, which can be reversed with anti-tumor necrosis factor-α therapy and correlates with aortic stiffness reduction.

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          Author and article information

          Journal
          Circulation
          Circulation
          Ovid Technologies (Wolters Kluwer Health)
          1524-4539
          0009-7322
          Nov 20 2012
          : 126
          : 21
          Affiliations
          [1 ] Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. km391@cam.ac.uk
          Article
          CIRCULATIONAHA.112.120410
          10.1161/CIRCULATIONAHA.112.120410
          23095282
          16b5b7dc-e066-4f1a-8fc1-3e293081b39c
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