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      Increased Sensitivity of Mouse Mammary Gland for Hormones and Tumor Promoter 12–O-Tetradecanoyl-Phorbol-13-Acetate in Tissues Containing the Mtv-2 Gene

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          Abstract

          We have compared the response of mammary explants obtained from GR mice with those derived from GR/Mtv-2<sup>-</sup> congenic mice towards hormones and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). In explants of the mammary glands of virgin GR mice, insulin, prolactin, progesterone and TPA stimulated the rate of (3H)-thymidine incorporation into DNA. A significantly lower response towards prolactin and TPA was observed in mammary explants derived from GR/Mtv-2<sup>-</sup> mice. The differential sensitivity of mammary tissues from GR and GR/Mtv-2<sup>-</sup>mouse strains to the actions of prolactin and tumor promoter is directly correlated to their different incidences of spontaneous tumor formation; it is not known if there is a causal relationship.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1984
          1984
          26 November 2008
          : 19
          : 1
          : 52-56
          Affiliations
          aDepartment of Physiology, Wayne State University, School of Medicine, Detroit, Mich., USA; bDivision of Endocrinology, Antoni van Leeuwenhoekhuis, The Netherlands Cancer Institute, Amsterdam, The Netherlands
          Article
          179868 Horm Res 1984;19:52–56
          10.1159/000179868
          6363246
          16ce4a35-c159-4a05-84ed-67c271cd7a1c
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 07 October 1982
          : 08 March 1983
          Page count
          Pages: 5
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          3H-thymidine incorporation,Mammary gland,TPA,Insulin,Progesterone,Prolactin,DNA,Mtv-2 gene

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