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      Increased Sensitivity of Mouse Mammary Gland for Hormones and Tumor Promoter 12–O-Tetradecanoyl-Phorbol-13-Acetate in Tissues Containing the Mtv-2 Gene

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          We have compared the response of mammary explants obtained from GR mice with those derived from GR/Mtv-2<sup>-</sup> congenic mice towards hormones and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). In explants of the mammary glands of virgin GR mice, insulin, prolactin, progesterone and TPA stimulated the rate of (3H)-thymidine incorporation into DNA. A significantly lower response towards prolactin and TPA was observed in mammary explants derived from GR/Mtv-2<sup>-</sup> mice. The differential sensitivity of mammary tissues from GR and GR/Mtv-2<sup>-</sup>mouse strains to the actions of prolactin and tumor promoter is directly correlated to their different incidences of spontaneous tumor formation; it is not known if there is a causal relationship.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 19
          : 1
          : 52-56
          aDepartment of Physiology, Wayne State University, School of Medicine, Detroit, Mich., USA; bDivision of Endocrinology, Antoni van Leeuwenhoekhuis, The Netherlands Cancer Institute, Amsterdam, The Netherlands
          179868 Horm Res 1984;19:52–56
          © 1984 S. Karger AG, Basel

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          Pages: 5


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