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      Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats.


      Titanium, Animals, Bone and Bones, drug effects, pathology, radiography, Calcium Phosphates, pharmacology, Coated Materials, Biocompatible, Collagen Type I, Female, Implants, Experimental, Organ Size, Osteogenesis, Osteoporosis, physiopathology, Rats, Rats, Wistar, Reproducibility of Results, Wound Healing, X-Ray Microtomography

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          This study hypothesized that modification of titanium implant surface, e.g. by the deposition of inorganic/organic coatings, can significantly improve the implant-bone response compared in osteoporotic vs. healthy conditions. After osteoporosis was induced in 15 female Wistar rats by ovariectomy (OVX) and confirmed by in vivo micro-CT analysis, implants coated with calcium phosphate (CaP) or collagen type-I and non-coated implants were placed into bilateral femoral condyles. Another 15 sham-operated rats served as controls. Twelve weeks after implantation, micro-CT bone volume (%BV) and histomorphometrical bone area (%BA) were lower around control implants in osteoporotic rats (BV = 60.4%, BA = 43.8%) compared to sham-operated rats (BV = 74.0%, BA = 62.0%). Interestingly, CaP and collagen type-I surface coatings enhanced bone-to-implant contact (%BIC) compared to non-coated implants in osteoporosis (51.9%, 58.2%) as well as in sham-operated (69.7%, 64.4%) groups. The study confirmed that an osteoporotic condition has a significant effect on the amount of bone present in close vicinity to implants. Evidently, the use of osteogenic surface coatings has a favorable effect on the bone implant interface in both osteoporotic and sham-operated conditions. Copyright © 2013 Elsevier Ltd. All rights reserved.

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