Androgen Effects on Follicle-Stimulating Hormone (FSH) Secretion in Organ Culture

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Abstract

The effects of testosterone, dihydrotestosterone, and otherandrogens upon gonadotropin secretion were studied using isolated female rat pituitaries maintained for 5 days. FSH and luteinizing hormone (LH) were measured by radioimmunoassay. When mean FSH release and mean final tissue content of FSH were compared in preparations containing testosterone or dihydrotestosterone (5 ng/ml) in the presence of 4 × 10<sup>–4</sup> M dibutyryl cyclic AMP (vs dbcAMP alone), both release and tissue content were significantly increased. Dihydrotestosterone, but not testosterone, significantly reduced LH release. Similiarly, in experiments utilizing LH-releasing hormone (LRH, 1.5 ng/ml), a significant increase in FSH release (128% of control values during the final 3 days of culture) and a significant increase in tissue content (152% of control values) were obtained in the presence of testosterone. Thus, testosterone in the presence of LRH did not inhibit gonadotropin release; rather, the secretion of FSH seemed to be stimulated.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 20 March 2008

Volume: 16

Issue: 5-6

Pages: 265-272

Affiliations

Medical Service, Veterans Administration Hospital, East Orange, N.J., and Department of Medicine, New Jersey Medical School, Newark, N.J.

Article

Publisher ID: 122573 Other ID: Neuroendocrinology 1974;16:265–272

DOI: 10.1159/000122573

PubMed ID: 4375261

SO-VID: 16e32c71-66f1-4eca-99e9-573c112a8f32

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 February 1974

Date accepted : 08 July 1974

Page count

Pages: 8

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