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      Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus.

      Journal of Biology

      Aphidicolin, pharmacology, Base Sequence, DNA, Circular, biosynthesis, DNA, Complementary, DNA, Viral, Genetic Vectors, HIV-1, growth & development, HeLa Cells, Humans, Leukemia Virus, Murine, Mitosis, drug effects, Molecular Sequence Data, S Phase

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          Abstract

          The human immunodeficiency virus productively infects and integrates into cells that have been arrested in the cell cycle with either gamma irradiation or aphidicolin. Integration by oncoretroviruses such as the murine leukemia virus (MuLV), on the other hand, depends on cell proliferation. Although the entire cell cycle is not necessary for MuLV infection, it is essential that the infected cells pass through mitosis. The long terminal repeat circle junction, a marker for nuclear entry, is first observed in MuLV-infected cells immediately after mitosis. These results suggest that mitosis is necessary for nuclear entry of MuLV, but not human immunodeficiency virus, unintegrated proviral DNA.

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          8254763
          236313

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