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      Comparative safety profile of hyaluronic acid products for knee osteoarthritis: a systematic review and network meta-analysis.

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          Abstract

          Intra-articular (IA) hyaluronic acid (HA) is considered a safer alternative to oral Non-Steroidal Antiinflammatory Drugs (NSAIDs) and opioids for knee osteoarthritis (OA). A recent review raised potential safety concerns about HA, warranting further review of safety outcomes. We examined the risks of HA compared with IA placebo and investigated whether the risks vary among individual HA preparations.

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          Author and article information

          Journal
          Osteoarthr. Cartil.
          Osteoarthritis and cartilage
          Elsevier BV
          1522-9653
          1063-4584
          Dec 2016
          : 24
          : 12
          Affiliations
          [1 ] Center for Treatment Comparison and Integrative Analysis (CTCIA), Division of Rheumatology, Tufts Medical Center, Boston, MA, USA. Electronic address: rbannuru@tuftsmedicalcenter.org.
          [2 ] Center for Treatment Comparison and Integrative Analysis (CTCIA), Division of Rheumatology, Tufts Medical Center, Boston, MA, USA.
          Article
          S1063-4584(16)30196-0
          10.1016/j.joca.2016.07.010
          27492466
          16f3ce4c-f70f-4eca-a997-c20900ce6651
          History

          Hyaluronic acid,Safety,Osteoarthritis,Knee,Intra-articular therapy

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