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Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's disease, and controls.
Ilonka Eisensehr
1 ,
Reiner Linke ,
Klaus Tatsch ,
Bita Kharraz ,
Josef F Gildehaus ,
Christian T Wetter ,
Claudia Trenkwalder ,
Johannes Schwarz ,
Soheyl Noachtar
Aug 1 2003
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Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by complex behavior during REM sleep. The etiology of this disorder is still unknown, but a recent study showed that RBD precedes symptoms of Parkinson disease (PD) by several years, and in a previous study, we found reduced striatal dopamine transporters in idiopathic clinically manifest RBD.