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      Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

      Nature

      Xenopus laevis, Adenosine Triphosphate, Sequence Homology, Amino Acid, Second Messenger Systems, Rats, metabolism, genetics, RNA, Messenger, RNA, Protein Structure, Secondary, Protein Conformation, physiology, drug effects, Potassium Channels, Poly A, Open Reading Frames, Oocytes, Molecular Sequence Data, Models, Structural, Membrane Potentials, Kidney Medulla, Ion Channel Gating, Female, Cloning, Molecular, Chlorides, ultrastructure, Cell Membrane, Base Sequence, Barium Compounds, pharmacology, Barium, Animals, Amino Acid Sequence

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          Abstract

          A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.

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          Journal
          10.1038/362031a0
          7680431

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