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      An Effective LSTM Recurrent Network to Detect Arrhythmia on Imbalanced ECG Dataset

      research-article
      1 , 1 , 2 , 3 , 1 ,
      Journal of Healthcare Engineering
      Hindawi

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          Abstract

          To reduce the high mortality rate from cardiovascular disease (CVD), the electrocardiogram (ECG) beat plays a significant role in computer-aided arrhythmia diagnosis systems. However, the complex variations and imbalance of ECG beats make this a challenging issue. Since ECG beat data exist in heavily imbalanced category, an effective long short-term memory (LSTM) recurrence network model with focal loss (FL) is proposed. For this purpose, the LSTM network can disentangle the timing features in complex ECG signals, while the FL is used to resolve the category imbalance by downweighting easily identified normal ECG examples. The advantages of the proposed network have been verified in the MIT-BIH arrhythmia database. Experimental results show that the LSTM network with FL achieved a reliable solution to the problem of imbalanced datasets in ECG beat classification and was not sensitive to quality of ECG signals. The proposed method can be deployed in telemedicine scenarios to assist cardiologists into more accurately and objectively diagnosing ECG signals.

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          Most cited references27

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          Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network

          Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow1. Widely available digital ECG data and the algorithmic paradigm of deep learning2 present an opportunity to substantially improve the accuracy and scalability of automated ECG analysis. However, a comprehensive evaluation of an end-to-end deep learning approach for ECG analysis across a wide variety of diagnostic classes has not been previously reported. Here, we develop a deep neural network (DNN) to classify 12 rhythm classes using 91,232 single-lead ECGs from 53,549 patients who used a single-lead ambulatory ECG monitoring device. When validated against an independent test dataset annotated by a consensus committee of board-certified practicing cardiologists, the DNN achieved an average area under the receiver operating characteristic curve (ROC) of 0.97. The average F1 score, which is the harmonic mean of the positive predictive value and sensitivity, for the DNN (0.837) exceeded that of average cardiologists (0.780). With specificity fixed at the average specificity achieved by cardiologists, the sensitivity of the DNN exceeded the average cardiologist sensitivity for all rhythm classes. These findings demonstrate that an end-to-end deep learning approach can classify a broad range of distinct arrhythmias from single-lead ECGs with high diagnostic performance similar to that of cardiologists. If confirmed in clinical settings, this approach could reduce the rate of misdiagnosed computerized ECG interpretations and improve the efficiency of expert human ECG interpretation by accurately triaging or prioritizing the most urgent conditions.
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            Arrhythmia detection using deep convolutional neural network with long duration ECG signals

            This article presents a new deep learning approach for cardiac arrhythmia (17 classes) detection based on long-duration electrocardiography (ECG) signal analysis. Cardiovascular disease prevention is one of the most important tasks of any health care system as about 50 million people are at risk of heart disease in the world. Although automatic analysis of ECG signal is very popular, current methods are not satisfactory. The goal of our research was to design a new method based on deep learning to efficiently and quickly classify cardiac arrhythmias. Described research are based on 1000 ECG signal fragments from the MIT - BIH Arrhythmia database for one lead (MLII) from 45 persons. Approach based on the analysis of 10-s ECG signal fragments (not a single QRS complex) is applied (on average, 13 times less classifications/analysis). A complete end-to-end structure was designed instead of the hand-crafted feature extraction and selection used in traditional methods. Our main contribution is to design a new 1D-Convolutional Neural Network model (1D-CNN). The proposed method is 1) efficient, 2) fast (real-time classification) 3) non-complex and 4) simple to use (combined feature extraction and selection, and classification in one stage). Deep 1D-CNN achieved a recognition overall accuracy of 17 cardiac arrhythmia disorders (classes) at a level of 91.33% and classification time per single sample of 0.015 s. Compared to the current research, our results are one of the best results to date, and our solution can be implemented in mobile devices and cloud computing.
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              A novel wavelet sequence based on deep bidirectional LSTM network model for ECG signal classification

              Long-short term memory networks (LSTMs), which have recently emerged in sequential data analysis, are the most widely used type of recurrent neural networks (RNNs) architecture. Progress on the topic of deep learning includes successful adaptations of deep versions of these architectures. In this study, a new model for deep bidirectional LSTM network-based wavelet sequences called DBLSTM-WS was proposed for classifying electrocardiogram (ECG) signals. For this purpose, a new wavelet-based layer is implemented to generate ECG signal sequences. The ECG signals were decomposed into frequency sub-bands at different scales in this layer. These sub-bands are used as sequences for the input of LSTM networks. New network models that include unidirectional (ULSTM) and bidirectional (BLSTM) structures are designed for performance comparisons. Experimental studies have been performed for five different types of heartbeats obtained from the MIT-BIH arrhythmia database. These five types are Normal Sinus Rhythm (NSR), Ventricular Premature Contraction (VPC), Paced Beat (PB), Left Bundle Branch Block (LBBB), and Right Bundle Branch Block (RBBB). The results show that the DBLSTM-WS model gives a high recognition performance of 99.39%. It has been observed that the wavelet-based layer proposed in the study significantly improves the recognition performance of conventional networks. This proposed network structure is an important approach that can be applied to similar signal processing problems.
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                Author and article information

                Contributors
                Journal
                J Healthc Eng
                J Healthc Eng
                JHE
                Journal of Healthcare Engineering
                Hindawi
                2040-2295
                2040-2309
                2019
                13 October 2019
                : 2019
                : 6320651
                Affiliations
                1Cooperative Innovation Center of Internet Healthcare, Zhengzhou University, Zhengzhou 450000, China
                2State Key Laboratory of Mathematical Engineering and Advanced Computing, Zhengzhou 450001, China
                3Department of Automation, School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China
                Author notes

                Guest Editor: Liang Zou

                Author information
                https://orcid.org/0000-0002-8006-2564
                https://orcid.org/0000-0003-3485-8470
                https://orcid.org/0000-0002-1125-9507
                https://orcid.org/0000-0001-9204-5414
                Article
                10.1155/2019/6320651
                6815557
                31737240
                1729fbdc-59cf-4b56-b6ab-98a4955a2521
                Copyright © 2019 Junli Gao et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 19 April 2019
                : 4 June 2019
                : 19 June 2019
                Funding
                Funded by: Cloud Computing and Big Integration of Cloud Computing and Big Data, Innovation of Science and Education
                Award ID: 2017A11017
                Funded by: CERNET Innovation Project
                Award ID: NGII20161202
                Funded by: Key Research, Development, and Dissemination Program of Henan Province
                Award ID: 182207310002
                Funded by: Xinjiang Production and Construction Corps
                Award ID: 2018AB017
                Categories
                Research Article

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