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      The miscibility and spatial distribution of the components in electrospun polymer–protein mats†

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      RSC Advances
      The Royal Society of Chemistry

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          Abstract

          Biodegradable blended electrospun mats are promising for biomedical applications such as wound dressing, tissue engineering, and drug delivery. Electrospun mats based on polyesters can be modified by the addition of other polymers or proteins to accelerate the degradation, improve mechanical properties or biocompatibility. However, relatively little is known about the distribution of the components throughout the blended mats. In the present work, we prepared polylactide (PLA), bovine serum albumin (BSA), and the blended PLA–BSA electrospun mats. We demonstrated that PLA and BSA are miscible in a common solvent HFIP (1,1,1,3,3,3-hexafluoro-2-propanol) at concentrations below 3%, but become immiscible as concentration increases. We used three methods (fluorescence microscopy, EDX, and Raman microspectroscopy) to validate that PLA and BSA can be blended in a single electrospun fiber despite the phase separation in the blend. The homogeneity of the blend influences on the homogeneity of the distribution of PLA and BSA components throughout the electrospun mat, as measured by Raman microspectroscopy. When the blended electrospun mats were incubated in water, they demonstrated the prolonged release of BSA. The presented results show a step-by-step approach for manufacturing blended electrospun mats made of immiscible components, which involves the analysis of component miscibility, the mat morphology, and composition. This approach can be used for the rational design of multicomponent electrospun mats.

          Abstract

          Polylactide and bovine serum albumin can be combined in a single electrospun fiber, despite the phase separation.

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          Most cited references54

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          Electrospun polymer biomaterials

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            Flat polymer ribbons and other shapes by electrospinning

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              Effect of molecular weight on fibrous PVA produced by electrospinning

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                Author and article information

                Journal
                RSC Adv
                RSC Adv
                RA
                RSCACL
                RSC Advances
                The Royal Society of Chemistry
                2046-2069
                29 January 2020
                24 January 2020
                29 January 2020
                : 10
                : 8
                : 4672-4680
                Affiliations
                [a] Federal Research Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency of Russia 1a Malaya Pirogovskaya Street 119435 Moscow Russian Federation
                [b] Moscow Institute of Physics and Technology 9 Institutsky Per., Dolgoprudny 141700 Moscow Region Russian Federation
                [c] Lomonosov Moscow State University, Faculty of Biology, Department of Bioengineering 1-12 Leninskie Gory 119234 Moscow Russian Federation bagrov@ 123456mail.bio.msu.ru
                Author information
                https://orcid.org/0000-0002-2511-7622
                https://orcid.org/0000-0002-4071-7693
                https://orcid.org/0000-0001-5369-8519
                https://orcid.org/0000-0002-6355-7282
                Article
                c9ra10910b
                10.1039/c9ra10910b
                9049090
                35495279
                1731fe2f-b6d3-41dd-ba21-21412d641b50
                This journal is © The Royal Society of Chemistry
                History
                : 25 December 2019
                : 17 January 2020
                Page count
                Pages: 9
                Funding
                Funded by: Russian Science Foundation, doi 10.13039/501100006769;
                Award ID: 19-74-00037
                Categories
                Chemistry
                Custom metadata
                Paginated Article

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