Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2).

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Abstract

Fibroblast growth factor (FGF)-2 is a critical growth factor in normal and malignant cell proliferation and tumor-associated angiogenesis. Fibrinogen and fibrin bind to FGF-2 and modulate FGF-2 functions. Furthermore, we have shown that extrahepatic epithelial cells are capable of endogenous production of fibrinogen.

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Journal

Journal ID (iso-abbrev): J Thromb Haemost

Title: Journal of thrombosis and haemostasis : JTH

Publisher: Wiley

ISSN: 1538-7933

ISSN (Print): 1538-7836

Publication date (Electronic): Jan 2008

Volume: 6

Issue: 1

Affiliations

[1 ] Hematology/Oncology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. abha_sahni@urmc.rochester.edu

Article

Publisher Item ID: S1538-7836(22)13186-7

DOI: 10.1111/j.1538-7836.2007.02808.x

PubMed ID: 17949478

SO-VID: 174c6553-28ee-47af-b2cc-8e71dab40c4a

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