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      Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis.

      Annals of Neurology

      Humans, Male, etiology, diagnosis, Basal Ganglia, pathology, Cell Count, Cholinergic Fibers, Dementia, Aged, Alzheimer Disease

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          Abstract

          The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.

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          Journal
          10.1002/ana.410100203
          7283399

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