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      The application of machine learning to balance a total knee arthroplasty

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          Abstract

          Aims

          The use of technology to assess balance and alignment during total knee surgery can provide an overload of numerical data to the surgeon. Meanwhile, this quantification holds the potential to clarify and guide the surgeon through the surgical decision process when selecting the appropriate bone recut or soft tissue adjustment when balancing a total knee. Therefore, this paper evaluates the potential of deploying supervised machine learning (ML) models to select a surgical correction based on patient-specific intra-operative assessments.

          Methods

          Based on a clinical series of 479 primary total knees and 1,305 associated surgical decisions, various ML models were developed. These models identified the indicated surgical decision based on available, intra-operative alignment, and tibiofemoral load data.

          Results

          With an associated area under the receiver-operator curve ranging between 0.75 and 0.98, the optimized ML models resulted in good to excellent predictions. The best performing model used a random forest approach while considering both alignment and intra-articular load readings.

          Conclusion

          The presented model has the potential to make experience available to surgeons adopting new technology, bringing expert opinion in their operating theatre, but also provides insight in the surgical decision process. More specifically, these promising outcomes indicated the relevance of considering the overall limb alignment in the coronal and sagittal plane to identify the appropriate surgical decision.

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          Most cited references27

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          Receiver operating characteristic curve in diagnostic test assessment.

          The performance of a diagnostic test in the case of a binary predictor can be evaluated using the measures of sensitivity and specificity. However, in many instances, we encounter predictors that are measured on a continuous or ordinal scale. In such cases, it is desirable to assess performance of a diagnostic test over the range of possible cutpoints for the predictor variable. This is achieved by a receiver operating characteristic (ROC) curve that includes all the possible decision thresholds from a diagnostic test result. In this brief report, we discuss the salient features of the ROC curve, as well as discuss and interpret the area under the ROC curve, and its utility in comparing two different tests or predictor variables of interest.
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            Comparing different supervised machine learning algorithms for disease prediction

            Background Supervised machine learning algorithms have been a dominant method in the data mining field. Disease prediction using health data has recently shown a potential application area for these methods. This study ai7ms to identify the key trends among different types of supervised machine learning algorithms, and their performance and usage for disease risk prediction. Methods In this study, extensive research efforts were made to identify those studies that applied more than one supervised machine learning algorithm on single disease prediction. Two databases (i.e., Scopus and PubMed) were searched for different types of search items. Thus, we selected 48 articles in total for the comparison among variants supervised machine learning algorithms for disease prediction. Results We found that the Support Vector Machine (SVM) algorithm is applied most frequently (in 29 studies) followed by the Naïve Bayes algorithm (in 23 studies). However, the Random Forest (RF) algorithm showed superior accuracy comparatively. Of the 17 studies where it was applied, RF showed the highest accuracy in 9 of them, i.e., 53%. This was followed by SVM which topped in 41% of the studies it was considered. Conclusion This study provides a wide overview of the relative performance of different variants of supervised machine learning algorithms for disease prediction. This important information of relative performance can be used to aid researchers in the selection of an appropriate supervised machine learning algorithm for their studies.
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              Robotic-arm assisted total knee arthroplasty is associated with improved early functional recovery and reduced time to hospital discharge compared with conventional jig-based total knee arthroplasty

              Aims The objective of this study was to compare early postoperative functional outcomes and time to hospital discharge between conventional jig-based total knee arthroplasty (TKA) and robotic-arm assisted TKA. Patients and Methods This prospective cohort study included 40 consecutive patients undergoing conventional jig-based TKA followed by 40 consecutive patients receiving robotic-arm assisted TKA. All surgical procedures were performed by a single surgeon using the medial parapatellar approach with identical implant designs and standardized postoperative inpatient rehabilitation. Inpatient functional outcomes and time to hospital discharge were collected in all study patients. Results There were no systematic differences in baseline characteristics between the conventional jig-based TKA and robotic-arm assisted TKA treatment groups with respect to age (p = 0.32), gender (p = 0.50), body mass index (p = 0.17), American Society of Anesthesiologists score (p = 0.88), and preoperative haemoglobin level (p = 0.82). Robotic-arm assisted TKA was associated with reduced postoperative pain (p < 0.001), decreased analgesia requirements (p < 0.001), decreased reduction in postoperative haemoglobin levels (p < 0.001), shorter time to straight leg raise (p < 0.001), decreased number of physiotherapy sessions (p < 0.001) and improved maximum knee flexion at discharge (p < 0.001) compared with conventional jig-based TKA. Median time to hospital discharge in robotic-arm assisted TKA was 77 hours (interquartile range (IQR) 74 to 81) compared with 105 hours (IQR 98 to 126) in conventional jig-based TKA (p < 0.001). Conclusion Robotic-arm assisted TKA was associated with decreased pain, improved early functional recovery and reduced time to hospital discharge compared with conventional jig-based TKA. Cite this article: Bone Joint J 2018;100-B:930–7.
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                Author and article information

                Contributors
                Role: Director of Clinical Research & Development
                Role: Orthopedic Surgeon
                Role: Orthopaedic Surgeon
                Role: VP of Clinical Development
                Journal
                Bone Jt Open
                Bone Jt Open
                bjo
                Bone & Joint Open
                The British Editorial Society of Bone and Joint Surgery (London )
                2633-1462
                11 June 2020
                June 2020
                : 1
                : 6
                : 236-244
                Affiliations
                [1 ]org-divisionClinical Research & Development , Dania Beach, USA
                [2 ]org-divisionDept of Human Structure and Repair, Ghent University , Gent, Belgium
                [3 ]org-divisionSt Helena Hospital , Saint Helena, California, USA,
                [4 ]org-divisionOrthopedics , Holy Cross Hospital, Fort Lauderdale, Florida, USA
                [5 ]org-divisionOrthoSensor Inc , Dania Beach, Florida, USA,
                Author notes
                Correspondence should be sent to Matthias A. Verstraete. E-mail: Matthias.Verstraete@ 123456OrthoSensor.com
                Author information
                http://orcid.org/0000-0002-4708-4235
                Article
                BJO-1-236
                10.1302/2633-1462.16.BJO-2020-0056.R1
                7677727
                33225295
                175632e0-fe35-4c85-996e-707e3e1d6641
                © 2020 Author(s) et al.

                Open Access This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC-ND), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/.

                History
                Categories
                General Orthopaedics
                Custom metadata
                St. Helena Hospital, Saint Helena, California, USA

                balancing,machine learning,total knee arthroplasty
                balancing, machine learning, total knee arthroplasty

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