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      Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells

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          Abstract

          Morusin which has been isolated from the root bark of Morus alba L. (Moraceae) has previously demonstrated anticancer activity in various types of cancer cells such as hepatocellular carcinoma, glioma and prostate cancer. However, the effect of morusin on breast cancer cells remains unclear. In the present study, the potential of morusin as an anti-cancer agent in breast cancer was investigated. The results of the present study revealed that the treatment of morusin induced cell death in various human breast cancer cell lines, but exhibited little effect on normal human breast epithelial cells. In Annexin V-propidium iodide double staining assays, morusin significantly increased apoptosis in a dose-dependent manner in human breast cancer cells. The apoptosis marker proteins cleaved caspase 3 and 9 were consistently upregulated following treatment of cells with morusin in a time- and dose-dependent manner. Furthermore, morusin was demonstrated to modulate the expression of the anti-apoptotic protein Survivin and pro-apoptotic protein B-cell lymphoma 2-associated-x protein (Bax) in human breast cancer cells. These results indicate that morusin induces apoptosis by suppressing Survivin and inducing Bax proteins, suggesting that morusin is a potentially effective therapeutic agent for the treatment of patients with breast cancer.

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          Author and article information

          Journal
          Oncol Lett
          Oncol Lett
          OL
          Oncology Letters
          D.A. Spandidos
          1792-1074
          1792-1082
          June 2017
          07 April 2017
          07 April 2017
          : 13
          : 6
          : 4558-4562
          Affiliations
          [1 ]Department of Cancer Preventive Material Development, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
          [2 ]Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
          [3 ]Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
          [4 ]Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital, Seoul 05006, Republic of Korea
          [5 ]Department of Bioindustry and Bioresource Engineering, College of Life Sciences, Sejong University, Seoul 05006, Republic of Korea
          [6 ]KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea
          Author notes
          Correspondence to: Dr Seok-Geun Lee, Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea, E-mail: seokgeun@ 123456khu.ac.kr
          Dr Miyong Yun, Department of Bioindustry and Bioresource Engineering, College of Life Sciences, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of Korea, E-mail: myyun91@ 123456gmail.com
          Article
          PMC5453030 PMC5453030 5453030 OL-0-0-6006
          10.3892/ol.2017.6006
          5453030
          28599457
          176a6753-4ba4-432d-a7ed-d778e6128da4
          Copyright © 2017, Spandidos Publications
          History
          : 03 November 2015
          : 17 February 2017
          Categories
          Articles

          Survivin,apoptosis regulator Bax,apoptosis,breast cancer,morusin

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