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      Pulsed radiofrequency of dorsal root ganglion of upper thoracic segment for herpes zoster neuralgia : Case report

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          Abstract

          Rationale:

          Pulsed radiofrequency (PRF) therapy of dorsal root ganglion is effective in treating acute stage shingles neuralgia of chest and back. Herein, a case of herpetic neuralgia with difficult puncture of dorsal root ganglion of upper thoracic segment is report.

          Patient concerns:

          A 62-year-old male patient was admitted to the hospital for 2 days for herpes zoster with paroxysmal needle-like pain in the left chest and back. The skin lesion area of herpes zoster and the superficial location of neuralgia was left T2–4, and visual analog scale (VAS) score was 6 points.

          Diagnosis:

          Two days ago, the patient had paroxysmal needle-like pain in the left chest and back, without herpes, and was admitted to the hospital for emergency treatment. Chest pain and myocardial infarction were considered; however, troponin, myocardial enzyme spectrum, and blood amylase were in the normal range. On the evening of the same day, the patient presented green bean-sized blisters distributed in clusters along the left T2–4 nerve as a banded pattern. Thus, the patient was diagnosed as shingles.

          Intervention:

          Oral gabapentin capsules, varaciclovir tablets, mecobalamine tablets, and amitriptyline hydrochloride tablets were administered, and topical aciclovir cream was applied. The VAS score after the above treatment was 5 points. The patient underwent computed tomography-guided PRF surgery on the dorsal root ganglion.

          Outcome:

          Postoperative pain was relieved. One month post-surgery, no oral analgesic drugs were administered. The VAS score was 1 point, and the pain completely disappeared at 3 months post-surgery.

          Conclusions:

          Herpes zoster is most common in the chest and back. The PRF of dorsal root ganglion cannot access the target by conventional puncture, and can be completed by thoracic sympathetic nerve radiofrequency puncture path.

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          Most cited references9

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          Ultrastructural changes in axons following exposure to pulsed radiofrequency fields.

          Pulsed radiofrequency (PRF) fields applied by an electrode to neural structures, such as the peripheral sensory nociceptor axons and dorsal root ganglion, are clinically effective in reducing pain and other neuropathic syndromes. However, a full understanding of the underlying mechanisms by which this occurs has not yet been clarified. In this study, PRF is applied to the afferent axons of the sciatic nerves of rats. A standard radiofrequency (RF) electrode and RF generator is used to apply the RF signal output to the sciatic nerve using standard PRF parameters that have been successfully used in clinical practice. The ultrastructure of the treated axons is observed after 10 days by electron microscopy. A control, sham application is simultaneously applied to the contralateral sciatic nerve to provide a statistical differential comparison. It is found that the internal ultrastructural components of the axons show microscopic damage after PRF exposure, including: abnormal membranes and morphology of mitochondria, and disruption and disorganization of microfilaments and microtubules. The damage appears to be more pronounced for C-fibers than for A-delta and A-beta fibers. The results are discussed in terms of internal electric field strengths and thermodynamic parameters.
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            Acute differential modulation of synaptic transmission and cell survival during exposure to pulsed and continuous radiofrequency energy.

            Pulsed radiofrequency, in which short bursts of radiofrequency energy are applied to nervous tissue, has been recently described as an alternative technique devoid of nerve injury, a subsequent side effect of thermal lesions created by continuous radiofrequency lesioning. Yet the mechanism of this effect remains unclear. In this study we compared the acute effects of pulsed versus continuous radiofrequency energy on impulse propagation and synaptic transmission in hippocampal slice cultures and on cell survival in cortical cultures. A differential effect was observed on both systems, with pulsed radiofrequency producing a transient and continuous radiofrequency a lasting inhibition of evoked synaptic activity. In addition, although both continuous radiofrequency and pulsed radiofrequency treatments induced a distance-dependent tissue destruction under the stimulating needle, the effect was more pronounced in the continuous radiofrequency group. These findings suggest that the acute effects of pulsed radiofrequency are more reversible and less destructive in nature than the classic continuous radiofrequency mode, even in normothermal conditions. This model might help elucidate the importance of various parameters for the clinical application of radiofrequency lesioning and might open new horizons for the role of pulsed radiofrequency lesioning in cases of neuropathic pain.
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              Risk Factors for Herpes Zoster: a Systematic Review and Meta-Analysis

              Abstract Background Well-recognized risk factors for herpes zoster (HZ), commonly known as shingles, are age and immunosuppression. Numerous studies have investigated other various risk factors for HZ in recent years. The objective of our study is to systematically review studies examining risk factors for HZ and discuss implications based on the updated evidence. Methods We performed a literature search using PubMed, Embase, and Web of Science and included studies that examined risk factors for HZ. Random effects model was used to summarize the risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI). Results Of the 3450 studies screened, we included 84 studies in the systematic review and conducted meta-analysis in 62 studies. Women are at increased risk of HZ compared with men (pooled adjusted RR = 1.31; 95% CI: 1.27, 1.34). Black individuals have almost half the risk of HZ than White individuals (pooled RR = 0.54; 95% CI: 0.47, 0.63). Family history was found to be a risk factor for HZ (pooled OR = 3.59; 95% CI: 2.39, 5.40). Autoimmune diseases, including rheumatoid arthritis (pooled RR = 1.67; 95% CI: 1.41, 1.98) and systemic lupus erythematous (RR = 2.10; 95% CI: 1.40, 3.15), were associated with an elevated risk of HZ. Other comorbidities were associated with an increased risk of HZ, with the pooled RRs ranging from 1.25 (95% CI: 1.13, 1.39) for asthma to 1.30 (1.17, 1.45) for diabetes mellitus, and 1.31 (95% CI: 1.22, 1.41) for chronic obstructive pulmonary disease. Statin use was also associated with a modest increased risk of HZ (pooled RR = 1.14; 95% CI: 1.11, 1.17). Recent physical trauma increased risk of HZ by almost two-fold (pooled RR = 2.56; 95% CI: 1.97, 3.33). Conclusion In addition to age and immunocompromised conditions, our review shows that female sex, race/ethnicity, family history, and comorbidities are risk factors for HZ. Efforts are needed to better understand risk factors and to increase the uptake of zoster vaccination. Disclosures B. P. Yawn, GSK: Consultant and Scientific Advisor, Consulting fee
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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Wolters Kluwer Health
                0025-7974
                1536-5964
                19 June 2020
                19 June 2020
                : 99
                : 25
                : e20807
                Affiliations
                Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
                Author notes
                []Correspondence: Tingting Wang, Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University, 1882 ZhongHuan South Road, Jiaxing 314001 Zhejiang, China (e-mail: wangtingting2045@ 123456163.com ).
                Article
                MD-D-19-08655 20807
                10.1097/MD.0000000000020807
                7310828
                32569227
                1777bee9-adcf-4065-b029-c65a85c7b20c
                Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

                History
                : 15 November 2019
                : 1 May 2020
                : 21 May 2020
                Funding
                Funded by: the Science and Technology Project of Jiaxing City
                Award ID: 2019AD32150
                Award Recipient : Not Applicable
                Funded by: Construction Project of Anesthesiology Discipline Special Disease Center in Zhejiang North Region
                Award ID: 201524
                Award Recipient : Not Applicable
                Funded by: Zhejiang Province and Jiaxing City Jointly Established Key Medical Subjects-Pain Medicine
                Award ID: 2019-ss-ttyx
                Award Recipient : Not Applicable
                Categories
                3700
                Research Article
                Clinical Case Report
                Custom metadata
                TRUE

                dorsal root ganglion,pulsed radiofrequency,thoracic sympathetic nerve

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