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      Amiodarone induced epididymo-orchitis

      case-report
      a , , a , b , c
      Urology Case Reports
      Elsevier

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          Abstract

          Amiodarone has a well-established and extensive side effect profile: pulmonary fibrosis, thyroid toxicity, corneal deposits, and skin discoloration. However, in some rare instances epididymitis/orchitis is a side effect of amiodarone. Symptoms range from testicular pain to swelling and erythema. 1,2 The mechanism of how this toxicity occurs is unknown. In this case report, we will discuss the case of an elderly patient who developed epididymitis and orchitis after several years of tolerating amiodarone without any adverse events. Our patient underwent a full workup with testicular ultrasound, evaluation by the urology and cardiology services. His amiodarone was discontinued with complete resolution of symptoms.

          Data sources

          A community hospital in Stratford, NJ.

          Study selection

          88 year old male patient with multiple comorbidities.

          Data extraction

          Obtaining medical records on Soarian Cerner system.

          Data synthesis

          Article analysis obtained from PubMed.

          Related collections

          Most cited references4

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          A practical guide for clinicians who treat patients with amiodarone: 2007.

          Amiodarone is commonly used to treat supraventricular and ventricular arrhythmias in various inpatient and outpatient settings. Over- and under-use of amiodarone is common, and data regarding patterns of use are sparse and largely anecdotal. Because of adverse drug reactions, proper use is essential to deriving optimal benefits from the drug with the least risk. This guide updates an earlier version published in 2000, reviews indications for use of amiodarone and recommends strategies to minimize adverse effects. The recommendations included herein are based on the best available data and the collective experience of the member of the writing committee.
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            • Article: not found

            The clinical spectrum of the presenting signs and symptoms of anterior urethral stricture: detailed analysis of a single institutional cohort.

            To accurately delineate the presentation of anterior urethral stricture in an economically developed patient cohort. It is widely assumed that patients with urethral stricture typically present with lower urinary tract symptoms (LUTS). There is a paucity of data examining this assumption. With no uniformly accepted clinical definition or measure of treatment success, a clear clinical description of urethral stricture is important.
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              Amiodarone-induced epididymitis: a case report and review of the literature.

              Epididymitis, as an unusual side-effect of amiodarone use, in a patient with dilated cardiomyopathy is reported along with a pertinent literature review. The diagnosis was one of exclusion after the patient received several regimens of antimicrobials and was only established after a dose reduction of the amiodarone regimen. Cardiologists should be aware of this rare but existing side effect of amiodarone, in order promptly intervene with dose adjustment or discontinuation of amiodarone and to avoid prolonged use of unnecessary antimicrobial regimens.
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                Author and article information

                Contributors
                Journal
                Urol Case Rep
                Urol Case Rep
                Urology Case Reports
                Elsevier
                2214-4420
                31 May 2019
                September 2019
                31 May 2019
                : 26
                : 100929
                Affiliations
                [a ]Internal Medicine, Rowan University School of Osteopathic Medicine, 1 Medical Center Drive, Stratford, NJ, 08084, USA
                [b ]Urological Surgery, Rowan University School of Osteopathic Medicine, 1 Medical Center Drive, Stratford, NJ, 08084, USA
                [c ]Internal Medicine, Cardiovascular Disease, Cooper Cardiology, 900 Centennial Boulevard, Building 2, Voorhees, NJ, 08043, USA
                Author notes
                []Corresponding author. dasu@ 123456rowan.edu
                Article
                S2214-4420(19)30141-X 100929
                10.1016/j.eucr.2019.100929
                6556547
                31198686
                177a5070-35a0-4bab-8ba2-3cfa6f975779
                © 2019 Published by Elsevier Inc.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 17 April 2019
                : 29 May 2019
                Categories
                Inflammation and Infection

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