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      Renal Function in Borderline Hypertensive First-Degree Relatives of Essential Hypertensives

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          Abstract

          Renal function in the basal state and after sodium load has been investigated in 21 borderline, hypertensive, first-degree relatives of established hypertensives and in 21 age-and sex-matched, normal subjects with no family history of hypertension. During intravenous infusion of inulin and /?-aminohippurate in saline, both groups showed a decrease in plasma aldosterone levels (p < 0.05) but renal plasma flow (595 ± 48 vs. 750 ± 59 ml/min, p < 0.05), diuresis (1.4 ± 0.2 vs. 2.2 ± 0.5 ml/min, p < 0.05), natriuresis (0.21 ± 0.02 vs. 0.3 ± 0.02 mEq/min, p < 0.05) and sodium clearance (1.05 ± 0.1 vs. 2.4 ± 0.4 ml/min, p < 0.05) in borderline hypertensives were higher than in the control group. After the salt load (NaCl, 1.35% i.v., 5 ml/min for 2 h) there was an increase in blood pressure and a decrease in plasma aldosterone and potassium levels in both groups. However, borderline hypertensives showed higher diuresis, natriuresis, sodium clearance and also kaliuresis compared to normotensives. These results suggest that borderline hypertensives already present the changes in renal function which are characteristics of established hypertensives.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1982
          1982
          07 November 2008
          : 69
          : 5
          : 288-296
          Affiliations
          aIstituto di Patologia Speciale Medica, e bCattedra di Gerontologia e Geriatria, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italia
          Article
          173517 Cardiology 1982;69:288–296
          10.1159/000173517
          6756630
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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