Renal Function in Borderline Hypertensive First-Degree Relatives of Essential Hypertensives

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Abstract

Renal function in the basal state and after sodium load has been investigated in 21 borderline, hypertensive, first-degree relatives of established hypertensives and in 21 age-and sex-matched, normal subjects with no family history of hypertension. During intravenous infusion of inulin and /?-aminohippurate in saline, both groups showed a decrease in plasma aldosterone levels (p < 0.05) but renal plasma flow (595 ± 48 vs. 750 ± 59 ml/min, p < 0.05), diuresis (1.4 ± 0.2 vs. 2.2 ± 0.5 ml/min, p < 0.05), natriuresis (0.21 ± 0.02 vs. 0.3 ± 0.02 mEq/min, p < 0.05) and sodium clearance (1.05 ± 0.1 vs. 2.4 ± 0.4 ml/min, p < 0.05) in borderline hypertensives were higher than in the control group. After the salt load (NaCl, 1.35% i.v., 5 ml/min for 2 h) there was an increase in blood pressure and a decrease in plasma aldosterone and potassium levels in both groups. However, borderline hypertensives showed higher diuresis, natriuresis, sodium clearance and also kaliuresis compared to normotensives. These results suggest that borderline hypertensives already present the changes in renal function which are characteristics of established hypertensives.

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1982

Publication date (Print): 1982

Publication date (Electronic): 07 November 2008

Volume: 69

Issue: 5

Pages: 288-296

Affiliations

^aIstituto di Patologia Speciale Medica, e ^bCattedra di Gerontologia e Geriatria, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italia

Article

Publisher ID: 173517 Other ID: Cardiology 1982;69:288–296

DOI: 10.1159/000173517

PubMed ID: 6756630

SO-VID: 177d590b-babf-49dc-852a-bb6c5fa3e82c

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 14 March 1982

Date accepted : 16 June 1982

Page count

Pages: 9

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