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      Quantum dot-nucleic acid/aptamer bioconjugate-based fluorimetric biosensors.

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      Biochemical Society transactions

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          Abstract

          Over the last 10 years, fluorescent semiconductor QD (quantum dot)-biomolecule conjugates have emerged as a powerful new sensing platform showing great potential in a wide range of applications in biosensing, environmental monitoring and disease diagnosis. The present mini-review is a brief account of the recent developments in QD-NA (nucleic acid), particularly NA aptamer, conjugate-based biosensors using the FRET (Förster resonance energy transfer) readout mechanism. It starts with a brief introduction to the NA aptamer and QD-FRET, followed by example approaches to compact QD-DNA conjugates, target readout strategies and sensing performance, and concludes with challenges and outlook for the QD-NA/aptamer bioconjugate sensors.

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          Author and article information

          Journal
          Biochem. Soc. Trans.
          Biochemical Society transactions
          1470-8752
          0300-5127
          Aug 2012
          : 40
          : 4
          Affiliations
          [1 ] School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. d.zhou@leeds.ac.uk
          Article
          BST20120059
          10.1042/BST20120059
          22817707

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