Francesco Locatelli a , Thierry Hannedouche b , Alejandro Martin-Malo c , Stefan H. Jacobson d , Raymond Vanholder e , Claudio Ronco f , Vincenzo La Milia a , Juan M. Lopez Gomez g , Sergio Stefoni h , Hervé Maheut i , Marian Klinger j , Thierry Krummel b , Annemie Dhondt e , Isabel Berdud c , Adelheid Gauly k
28 March 2013
Background/Aims: The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. Methods: N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. Results: Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. Conclusions: NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.