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      Targeting metastatic cancer

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      Nature Medicine

      Springer Science and Business Media LLC

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          Abstract

          <p class="first" id="d4694438e83">Despite recent therapeutic advances in cancer treatment, metastasis remains the principal cause of cancer death. Recent work has uncovered the unique biology of metastasis-initiating cells that results in tumor growth in distant organs, evasion of immune surveillance and co-option of metastatic microenvironments. Here we review recent progress that is enabling therapeutic advances in treating both micro- and macrometastases. Such insights were gained from cancer sequencing, mechanistic studies and clinical trials, including of immunotherapy. These studies reveal both the origins and nature of metastases and identify new opportunities for developing more effective strategies to target metastatic relapse and improve patient outcomes. </p>

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          Author and article information

          Contributors
          (View ORCID Profile)
          Journal
          Nature Medicine
          Nat Med
          Springer Science and Business Media LLC
          1078-8956
          1546-170X
          January 2021
          January 13 2021
          January 2021
          : 27
          : 1
          : 34-44
          Article
          10.1038/s41591-020-01195-4
          7895475
          33442008
          © 2021

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