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      Vasopressin administration prevents functional recovery of the vasopressinergic neurosecretory system following neurohypophysectomy

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      Neuroscience Letters

      Elsevier BV

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          Abstract

          The rodent hypothalamic neurosecretory system normally exhibits remarkable functional and structural plasticity following injury. However, the present study describes a newly observed phenomenon in which neurohypophysectomized animals receiving chronically administered exogenous vasopressin during the post-lesion period (a treatment which insures maximal renal antidiuresis over this time frame) lose all capacity for recovery of antidiuretic function. Functional deficits are accompanied by a severe reduction in the number of neurons exhibiting immunohistochemical staining for arginine vasopressin. These data indicate that the presence of neurological stimulation signaling vasopressin release may play an important role in promoting neural regeneration of the vasopressinergic component of the neurosecretory system.

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          Author and article information

          Journal
          Neuroscience Letters
          Neuroscience Letters
          Elsevier BV
          03043940
          December 1986
          December 1986
          : 72
          : 3
          : 239-246
          Article
          10.1016/0304-3940(86)90520-3
          3822229
          © 1986

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