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      Dissolving Microneedles as Skin Allergy Test Device.

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          Abstract

          The possibility of using dissolving microneedles (DMs) as a skin allergy test device was studied in rats. Poly-L-arginine was used as a model allergen. Dextran was used to prepare three kinds of DM array chips containing different doses of poly-L-arginine: 17.1±0.5 µg (low-dose DM), 42.2±0.8 µg (medium-dose DM), and 87.4±1.1 µg (high-dose DM); each 1.0 cm2 chip contained 300 DMs. The mean lengths of the low-, medium-, and high-dose DM were 489±3, 485±3, and 492±1 µm and mean diameters of the base were 301±2, 299±1, and 299±2 µm, respectively. Furthermore, for the low-, medium-, and high-dose DM, the administered doses of poly-L-arginine were estimated to be 9.3±1.9, 31.1±1.3, and 61.9±4.7 µg and the scratching behavior per 30 min was 9.8±3.4, 60.4±8.3, and 95.7±10.6 times, respectively. These results demonstrate the dose dependence of the immunoreactivity of the poly-L-arginine DMs, suggesting that DMs can be used an alternative skin allergy device.

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          Author and article information

          Journal
          Biol Pharm Bull
          Biological & pharmaceutical bulletin
          Pharmaceutical Society of Japan
          1347-5215
          0918-6158
          2017
          : 40
          : 4
          Affiliations
          [1 ] Department of Pharmacokinetics, Kyoto Pharmaceutical University.
          Article
          10.1248/bpb.b16-00768
          28381808
          17b4d6d0-4cdf-4da3-93fc-6cd57fb21f47

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