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      Selenium Depletion in Hemodialysis Patients Treated with Polysulfone Membranes

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          Abstract

          Background/Aims: Epidemiological, animal and human studies have indicated that selenium deficiency is a risk factor for death from malignant diseases. The mechanisms that could modify selenium status may, therefore, be of particular interest in hemodialysis patients, considering their high cancer mortality rates. We aimed at evaluating the effect of hemodialysis with polysulfone membranes on selenium status. Methods: Twenty- eight chronically dialyzed patients and 32 age-matched healthy controls were enrolled in the study. Serum and dialysis fluid selenium concentrations, serum total protein, and hemoglobin concentrations and serum glutathione peroxidase activity were determined before and after the hemodialysis procedure. Results: The (mean ± SD) serum selenium and total protein concentrations and glutathione peroxidase activities were significantly (p < 0.05) higher in healthy controls (75.9 ± 8.3 µg/l, 78 ± 6 g/l, and 23.8 ± 4.8 mU/20 µl, respectively) than in the patients. There was no significant difference between serum selenium concentration before (63.6 ± 11.6 µg/l) and after (64.4 ± 11.4 µg/l) hemodialysis sessions, although hemoglobin and total serum protein concentrations and serum glutathione peroxidase activities increased (from 98.5 ± 1.3 to 114.8 ± 1.5 g/l, from 64 ± 8 to 71 ± 9 g/l, and from 16.8 ± 1.8 to 18.9 ± 1.9 mU/20 µl, respectively) significantly (p < 0.05) during hemodialysis, indicating hemoconcentration. The selenium concentration doubled, and protein appeared in the dialysates during dialysis session. The correlation of the selenium concentrations with the protein concentrations in the dialysate is significant (p < 0.01) with a Spearman R value of 0.97. Conclusion: The results of the present study suggest that selenium is lost through the pores of polysulfone membranes during hemodialysis which is associated with their protein permeability.

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          Most cited references 3

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          Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes

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            Determination of selenium in small volumes of blood plasma and serum by electrothermal atomic absorption spectrometry

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              Chemical forms of selenium in selenium containing proteins from human plasma

               J. Deagen (1991)
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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                2000
                February 2000
                28 January 2000
                : 84
                : 2
                : 119-123
                Affiliations
                aNational Institute of Rheumatology and Physiotherapy, Budapest, and bSemmelweis Medical University, Budapest, Hungary; cNational Public Health Institute of Finland, Helsinki, Finland
                Article
                45558 Nephron 2000;84:119–123
                10.1159/000045558
                10657711
                © 2000 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 2, References: 53, Pages: 5
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45558
                Categories
                Original Paper

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