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      Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety.

      Human Reproduction (Oxford, England)
      Blastocyst, physiology, Cost-Benefit Analysis, Embryo, Mammalian, Female, Humans, Infertility, Male, therapy, Male, Pregnancy, Pregnancy Outcome, Safety, Sperm Injections, Intracytoplasmic, adverse effects, economics

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          Abstract

          There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.

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