Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of two weeks of acute inactivity and recovery on glycemic control, integrated rates of muscle protein synthesis (MPS) in older men and women.

Related collections

Most cited references 31

Record: found
Abstract: found
Article: not found

International physical activity questionnaire: 12-country reliability and validity.

CORA L. CRAIG, ALISON L. MARSHALL, MICHAEL SJ??STR??M … (2003)

Physical inactivity is a global concern, but diverse physical activity measures in use prevent international comparisons. The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity. Between 1997 and 1998, an International Consensus Group developed four long and four short forms of the IPAQ instruments (administered by telephone interview or self-administration, with two alternate reference periods, either the "last 7 d" or a "usual week" of recalled physical activity). During 2000, 14 centers from 12 countries collected reliability and/or validity data on at least two of the eight IPAQ instruments. Test-retest repeatability was assessed within the same week. Concurrent (inter-method) validity was assessed at the same administration, and criterion IPAQ validity was assessed against the CSA (now MTI) accelerometer. Spearman's correlation coefficients are reported, based on the total reported physical activity. Overall, the IPAQ questionnaires produced repeatable data (Spearman's rho clustered around 0.8), with comparable data from short and long forms. Criterion validity had a median rho of about 0.30, which was comparable to most other self-report validation studies. The "usual week" and "last 7 d" reference periods performed similarly, and the reliability of telephone administration was similar to the self-administered mode. The IPAQ instruments have acceptable measurement properties, at least as good as other established self-reports. Considering the diverse samples in this study, IPAQ has reasonable measurement properties for monitoring population levels of physical activity among 18- to 65-yr-old adults in diverse settings. The short IPAQ form "last 7 d recall" is recommended for national monitoring and the long form for research requiring more detailed assessment.

0 comments Cited 3020 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Diagnosis and Classification of Diabetes Mellitus

Vittorio Basevi (2014)

0 comments Cited 884 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Five stages of evolving beta-cell dysfunction during progression to diabetes.

Gordon Weir, Susan Bonner-Weir (2004)

This article proposes five stages in the progression of diabetes, each of which is characterized by different changes in beta-cell mass, phenotype, and function. Stage 1 is compensation: insulin secretion increases to maintain normoglycemia in the face of insulin resistance and/or decreasing beta-cell mass. This stage is characterized by maintenance of differentiated function with intact acute glucose-stimulated insulin secretion (GSIS). Stage 2 occurs when glucose levels start to rise, reaching approximately 5.0-6.5 mmol/l; this is a stable state of beta-cell adaptation with loss of beta-cell mass and disruption of function as evidenced by diminished GSIS and beta-cell dedifferentiation. Stage 3 is a transient unstable period of early decompensation in which glucose levels rise relatively rapidly to the frank diabetes of stage 4, which is characterized as stable decompensation with more severe beta-cell dedifferentiation. Finally, stage 5 is characterized by severe decompensation representing a profound reduction in beta-cell mass with progression to ketosis. Movement across stages 1-4 can be in either direction. For example, individuals with treated type 2 diabetes can move from stage 4 to stage 1 or stage 2. For type 1 diabetes, as remission develops, progression from stage 4 to stage 2 is typically found. Delineation of these stages provides insight into the pathophysiology of both progression and remission of diabetes.

0 comments Cited 290 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: The Journals of Gerontology: Series A

Publisher: Oxford University Press (OUP)

ISSN (Print): 1079-5006

ISSN (Electronic): 1758-535X

Publication date Created: August 2018

Publication date Created: July 09 2018

Publication date Created: October 31 2017

Publication date Other: August 2018

Publication date (Print): July 09 2018

Publication date (Electronic): October 31 2017

Volume: 73

Issue: 8

Pages: 1070-1077

Affiliations

[1 ]Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

[2 ]Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

[3 ]Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada

[4 ]Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada

[5 ]Division of Physical Medicine and Rehabilitation, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Article

DOI: 10.1093/gerona/glx203

PMC ID: 6037059

PubMed ID: 29095970

SO-VID: 17f8c934-f054-49e8-bb82-63447031f0e5

License:

https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults

Read this article at

Abstract

Related collections

Synthesis of 2-trifluoromethylated piperidines and azepanes

Most cited references 31

International physical activity questionnaire: 12-country reliability and validity.

Diagnosis and Classification of Diabetes Mellitus

Five stages of evolving beta-cell dysfunction during progression to diabetes.

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 433

Cited by 47

Most referenced authors 724