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      Dissociation of Luteinizing Hormone and Follicle-Stimulating Hormone Control Mechanisms in Male and Female Rats by Neonatal Administration of Estradiol Benzoate or Testosterone Propionate

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          Abstract

          Testicular atrophy (TA) and decreased plasma luteinizing hormone (LH) levels were observed in the adult male rat after treatment with 500 µg of estradiol benzoate (EB) on the first day of life, while administration of 1 mg of testosterone propionate (TP) on the same day was also associated with TA but increased LH levels. TA and no changes in plasma LH levels were seen when the treatment was performed with similar doses of both steroids on day 5 of life. In no case were plasma follicle-stimulating hormone (FSH) levels altered by these treatments. No differences in basal LH and FSH levels were found in adult females after treatment with 100 µg of EB or 1 mg of TP on day 5. LH response to castration was lower in neonatally androgenized and estrogenized adult male and female rats than in their respective controls, while FSH response was scarcely modified. In conclusion, neonatal treatment with EB or TP in both sexes induced alterations in LH control mechanisms without changing those of FSH.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1984
          1984
          26 November 2008
          : 19
          : 2
          : 108-116
          Affiliations
          Departments of Physiology, Faculties of Medicine, aUniversities of Córdoba and bComplutensis of Madrid, Spain
          Article
          179875 Horm Res 1984;19:108–116
          10.1159/000179875
          6423508
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 9
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