+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Dissociation of Luteinizing Hormone and Follicle-Stimulating Hormone Control Mechanisms in Male and Female Rats by Neonatal Administration of Estradiol Benzoate or Testosterone Propionate

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Testicular atrophy (TA) and decreased plasma luteinizing hormone (LH) levels were observed in the adult male rat after treatment with 500 µg of estradiol benzoate (EB) on the first day of life, while administration of 1 mg of testosterone propionate (TP) on the same day was also associated with TA but increased LH levels. TA and no changes in plasma LH levels were seen when the treatment was performed with similar doses of both steroids on day 5 of life. In no case were plasma follicle-stimulating hormone (FSH) levels altered by these treatments. No differences in basal LH and FSH levels were found in adult females after treatment with 100 µg of EB or 1 mg of TP on day 5. LH response to castration was lower in neonatally androgenized and estrogenized adult male and female rats than in their respective controls, while FSH response was scarcely modified. In conclusion, neonatal treatment with EB or TP in both sexes induced alterations in LH control mechanisms without changing those of FSH.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 19
          : 2
          : 108-116
          Departments of Physiology, Faculties of Medicine, aUniversities of Córdoba and bComplutensis of Madrid, Spain
          179875 Horm Res 1984;19:108–116
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9


          Comment on this article