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      Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis

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      Molecular and Cellular Endocrinology

      Elsevier BV

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          Abstract

          Precise timing in hormone release from the hypothalamus, the pituitary and ovary is critical for fertility. Hormonal release patterns of the reproductive axis are regulated by a feedback loop within the hypothalamic-pituitary-gonadal (HPG) axis. The timing and rhythmicity of hormone release and tissue sensitivity in the HPG axis is regulated by circadian clocks located in the hypothalamus (suprachiasmatic nucleus, kisspeptin and GnRH neurons), the pituitary (gonadotrophs), the ovary (theca and granulosa cells), the testis (Leydig cells), as well as the uterus (endometrium and myometrium). The circadian clocks integrate environmental and physiological signals to produce cell endogenous rhythms generated by a transcriptional-translational feedback loop of transcription factors that are collectively called the “molecular clock”. This review specifically focuses on the contribution of molecular clock transcription factors in regulating hormone release patterns in the reproductive axis, with an emphasis on the female reproductive system. Specifically, we discuss the contributions of circadian rhythms in distinct neuronal populations of the female hypothalamus, the molecular clock in the pituitary and its overall impact on female and male fertility.

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          Author and article information

          Journal
          Molecular and Cellular Endocrinology
          Molecular and Cellular Endocrinology
          Elsevier BV
          03037207
          November 2019
          November 2019
          : 110655
          Article
          10.1016/j.mce.2019.110655
          6962569
          31756424
          © 2019

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