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      An atlas of the protein-coding genes in the human, pig, and mouse brain

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          Abstract

          The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          March 05 2020
          March 06 2020
          March 06 2020
          March 05 2020
          : 367
          : 6482
          : eaay5947
          Article
          10.1126/science.aay5947
          32139519
          180b2527-79c2-4030-a29c-d0a9fb31330b
          © 2020

          http://www.sciencemag.org/about/science-licenses-journal-article-reuse

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