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Osteoporosis: now and the future
Author(s):
Tilman D Rachner
,
Sundeep Khosla
,
Lorenz C Hofbauer
Publication date
Created:
April 2011
Publication date
(Print):
April 2011
Journal:
The Lancet
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Osteoporosis is a common disease characterised by a systemic impairment of bone mass and microarchitecture that results in fragility fractures. With an ageing population, the medical and socioeconomic effect of osteoporosis, particularly postmenopausal osteoporosis, will increase further. A detailed knowledge of bone biology with molecular insights into the communication between bone-forming osteoblasts and bone-resorbing osteoclasts and the orchestrating signalling network has led to the identification of novel therapeutic targets. Novel treatment strategies have been developed that aim to inhibit excessive bone resorption and increase bone formation. The most promising novel treatments include: denosumab, a monoclonal antibody for receptor activator of NF-κB ligand, a key osteoclast cytokine; odanacatib, a specific inhibitor of the osteoclast protease cathepsin K; and antibodies against the proteins sclerostin and dickkopf-1, two endogenous inhibitors of bone formation. This overview discusses these novel therapies and explains their underlying physiology. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Future Science Group: Coronavirus
Author and article information
Journal
Title:
The Lancet
Abbreviated Title:
The Lancet
Publisher:
Elsevier BV
ISSN (Print):
01406736
Publication date Created:
April 2011
Publication date (Print):
April 2011
Volume
: 377
Issue
: 9773
Pages
: 1276-1287
Article
DOI:
10.1016/S0140-6736(10)62349-5
PMC ID:
3555696
PubMed ID:
21450337
SO-VID:
180db121-cd19-4924-8804-333cee1af9e5
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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