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      The corticotrophin-releasing hormone test in preterm infants.

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          Abstract

          The developing hypothalamic--pituitary--adrenal axis (HPAA) may be immature and not yet fully functional in preterm infants. This may result in an inappropriate adrenal response to stress. Little is known about the pituitary--adrenal response to corticotrophin-releasing hormone (CRH) stimulation during the early neonatal period in preterm infants born before 32 weeks of gestation. Therefore, in a first study we investigated the pituitary--adrenal response to 1 microg/kg CRH i.v. in 13 preterm infants born less-than-or-equal 32 weeks of gestation. In addition, in a randomized placebo-controlled study we compared the pituitary--adrenal response of 1 microg/kg CRH to placebo and stimulation with 2 microg/kg CRH.

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          Author and article information

          Journal
          Clin. Endocrinol. (Oxf)
          Clinical endocrinology
          0300-0664
          0300-0664
          Feb 2002
          : 56
          : 2
          Affiliations
          [1 ] Research Institute of Endocrinology, Reproduction and Metabolism, VU University Medical Centre, Department of Pediatrics, Amsterdam, the Netherlands. roel.bolt@vumc.nl
          Article
          1467
          11874412

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