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      Origins of Renal Physiology in the USA


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          Research in renal physiology began later in the USA than in Europe. Initial studies in the early 1900s dealt with the pathophysiology of renal failure. Micropuncture study of single nephron function was initiated in the laboratory of A.N. Richards in the early 1920s and with the later addition of microperfusion provided important insights into the site and mechanisms of solute transport. In parallel, with the leadership of Homer Smith, the development of noninvasive clearance methods to measure glomerular filtration rate and renal blood flow initiated a fruitful period of quantification of renal hemodynamics and of transport by the tubules. The steady progress of renal physiology in the USA owes much to the generous support of basic reasearch by the National Institutes of Health. It is also worthy of mention that progress in renal physiology in the US owes much to work carried out in clinical departments and to the type of comparative studies exemplified by work at the Mt. Desert Island Biological Laboratory.

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            Author and article information

            Am J Nephrol
            American Journal of Nephrology
            S. Karger AG
            April 1999
            23 April 1999
            : 19
            : 2
            : 266-273
            Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Conn., USA
            13460 Am J Nephrol 1999;19:266–273
            © 1999 S. Karger AG, Basel

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            Page count
            Figures: 6, Tables: 3, References: 57, Pages: 8
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/13460
            Self URI (text/html): https://www.karger.com/Article/FullText/13460
            Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
            Origins of Renal Physiology (Dedicated to Carl Gottschalk)

            Cardiovascular Medicine,Nephrology
            National Institutes of Health,Clearance,Comparative physiology,Renal physiology,Micropuncture


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