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      Mapping digital health ecosystems in Africa in the context of endemic infectious and non-communicable diseases

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          Abstract

          Investments in digital health technologies such as artificial intelligence, wearable devices, and telemedicine may support Africa achieve United Nations (UN) Sustainable Development Goal for Health by 2030. We aimed to characterize and map digital health ecosystems of all 54 countries in Africa in the context of endemic infectious and non-communicable diseases (ID and NCD). We performed a cross-national ecological analysis of digital health ecosystems using 20-year data from the World Bank, UN Economic Commission for Africa, World Health Organization, and Joint UN Programme on HIV/AIDS. Spearman’s rank correlation coefficients were used to characterize ecological correlations between exposure (technology characteristics) and outcome (IDs and NCDs incidence/mortality) variables. Weighted linear combination model was used as the decision rule, combining disease burden, technology access, and economy, to explain, rank, and map digital health ecosystems of a given country. The perspective of our analysis was to support government decision-making. The 20-year trend showed that technology characteristics have been steadily growing in Africa, including internet access, mobile cellular and fixed broadband subscriptions, high-technology manufacturing, GDP per capita, and adult literacy, while many countries have been overwhelmed by a double burden of IDs and NCDs. Inverse correlations exist between technology characteristics and ID burdens, such as fixed broadband subscription and incidence of tuberculosis and malaria, or GDP per capita and incidence of tuberculosis and malaria. Based on our models, countries that should prioritize digital health investments were South Africa, Nigeria, and Tanzania for HIV; Nigeria, South Africa, and Democratic Republic of the Congo (DROC) for tuberculosis; DROC, Nigeria, and Uganda for malaria; and Egypt, Nigeria, and Ethiopia for endemic NCDs including diabetes, cardiovascular disease, respiratory diseases, and malignancies. Countries such as Kenya, Ethiopia, Zambia, Zimbabwe, Angola, and Mozambique were also highly affected by endemic IDs. By mapping digital health ecosystems in Africa, this study provides strategic guidance about where governments should prioritize digital health technology investments that require preliminary analysis of country-specific contexts to bring about sustainable health and economic returns. Building digital infrastructure should be a key part of economic development programs in countries with high disease burdens to ensure more equitable health outcomes. Though infrastructure developments alongside digital health technologies are the responsibility of governments, global health initiatives can cultivate digital health interventions substantially by bridging knowledge and investment gaps, both through technology transfer for local production and negotiation of prices for large-scale deployment of the most impactful digital health technologies.

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          Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025

          Diabetes mellitus is a leading cause of mortality and reduced life expectancy. We aim to estimate the burden of diabetes by type, year, regions, and socioeconomic status in 195 countries and territories over the past 28 years, which provide information to achieve the goal of World Health Organization Global Action Plan for the Prevention and Control of Noncommunicable Diseases in 2025. Data were obtained from the Global Burden of Disease Study 2017. Overall, the global burden of diabetes had increased significantly since 1990. Both the trend and magnitude of diabetes related diseases burden varied substantially across regions and countries. In 2017, global incidence, prevalence, death, and disability-adjusted life-years (DALYs) associated with diabetes were 22.9 million, 476.0 million, 1.37 million, and 67.9 million, with a projection to 26.6 million, 570.9 million, 1.59 million, and 79.3 million in 2025, respectively. The trend of global type 2 diabetes burden was similar to that of total diabetes (including type 1 diabetes and type 2 diabetes), while global age-standardized rate of mortality and DALYs for type 1 diabetes declined. Globally, metabolic risks (high BMI) and behavioral factors (inappropriate diet, smoking, and low physical activity) contributed the most attributable death and DALYs of diabetes. These estimations could be useful in policy-making, priority setting, and resource allocation in diabetes prevention and treatment.
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            Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks

            One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8.3 hours among the Korean population and 7.7 hours among the American adult population. Sedentary lifestyles are spreading worldwide because of a lack of available spaces for exercise, increased occupational sedentary behaviors such as office work, and the increased penetration of television and video devices. Consequently, the associated health problems are on the rise. A sedentary lifestyle affects the human body through various mechanisms. Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. Furthermore, it decreases cardiac output and systemic blood flow while activating the sympathetic nervous system, ultimately reducing insulin sensitivity and vascular function. It also alters the insulin-like growth factor axis and the circulation levels of sex hormones, which elevates the incidence of hormone-related cancers. Increased sedentary time impairs the gravitostat, the body’s weight homeostat, and weight gain, adiposity, and elevated chronic inflammation caused by sedentary behavior are risk factors for cancer. Sedentary behaviors have wide-ranging adverse impacts on the human body including increased all-cause mortality, cardiovascular disease mortality, cancer risk, and risks of metabolic disorders such as diabetes mellitus, hypertension, and dyslipidemia; musculoskeletal disorders such as arthralgia and osteoporosis; depression; and, cognitive impairment. Therefore, reducing sedentary behaviors and increasing physical activity are both important to promote public health.
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              The Lancet and Financial Times Commission on governing health futures 2030: growing up in a digital world

                Author and article information

                Contributors
                tsegahunm@gmail.com
                Journal
                NPJ Digit Med
                NPJ Digit Med
                NPJ Digital Medicine
                Nature Publishing Group UK (London )
                2398-6352
                26 May 2023
                26 May 2023
                2023
                : 6
                : 97
                Affiliations
                [1 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Addis Ababa University, College of Health Sciences, Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), ; Addis Ababa, Ethiopia
                [2 ]GRID grid.189967.8, ISNI 0000 0001 0941 6502, Emory University, Rollins School of Public Health, Hubert Department of Global Health, ; Atlanta, GA USA
                [3 ]GRID grid.189967.8, ISNI 0000 0001 0941 6502, Emory University, School of Medicine, Department of Family and Preventive Medicine, ; Atlanta, GA USA
                [4 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Addis Ababa University, College of Health Sciences, School of Medicine, ; Addis Ababa, Ethiopia
                [5 ]GRID grid.460724.3, ISNI 0000 0004 5373 1026, St. Paul’s Hospital Millennium Medical College, School of Public Health, ; Addis Ababa, Ethiopia
                [6 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Addis Ababa University, College of Health Sciences, School of Public Health, ; Addis Ababa, Ethiopia
                [7 ]GRID grid.189967.8, ISNI 0000 0001 0941 6502, Emory University, Rollins School of Public Health, Department of Behavioral, Social, and Health Education Sciences, ; Atlanta, GA USA
                [8 ]GRID grid.27755.32, ISNI 0000 0000 9136 933X, University of Virginia, School of Medicine, Department of Emergency Medicine, ; Charlottesville, VA USA
                [9 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Addis Ababa University, College of Health Sciences, ; Addis Ababa, Ethiopia
                [10 ]GRID grid.189967.8, ISNI 0000 0001 0941 6502, Emory University School of Medicine and Rollins School of Public Health, ; Atlanta, GA USA
                Author information
                http://orcid.org/0000-0002-8360-7574
                http://orcid.org/0000-0001-7266-2503
                http://orcid.org/0000-0003-1992-2470
                Article
                839
                10.1038/s41746-023-00839-2
                10213589
                37237022
                182f218a-c559-438d-b9b4-98ad8654eeb2
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 24 October 2022
                : 5 May 2023
                Funding
                Funded by: FundRef https://doi.org/10.13039/100000061, U.S. Department of Health & Human Services | NIH | Fogarty International Center (FIC);
                Award ID: D43TW011404
                Award ID: D43TW011404
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/100008374, Emory University | Center for AIDS Research, Emory University (CFAR);
                Award ID: P30AI050409
                Award ID: P30AI050409
                Award Recipient :
                Funded by: U.S. Department of Health & Human Services | NIH | Fogarty International Center (FIC)
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                © Springer Nature Limited 2023

                infectious diseases,cardiovascular diseases
                infectious diseases, cardiovascular diseases

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