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      Mechanisms of Left Ventricular Dysfunction Assessed by Layer-Specific Strain Analysis in Patients With Repaired Tetralogy of Fallot.

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          Abstract

          Left ventricular (LV) dysfunction in patients with repaired tetralogy of Fallot (rTOF) is an important risk factor for adverse outcomes. The aim of this study was to assess the details and time course of such LV dysfunction using layer-specific strain analysis by echocardiography.Methods and Results:The 66 patients with rTOF (mean age, 16.3±9.3 years) were divided into 3 groups (T1: 4-10 years, T2: 11-20 years, T3: 21-43 years), and 113 controls of similar age (mean age, 17.2±9.3 years) were divided into 3 corresponding groups (C1, C2, and C3). Layer-specific longitudinal strain (LS) and circumferential strain (CS) of 3 myocardial layers (endocardial, midmyocardial, and epicardial) were determined by echocardiography. Basal and papillary endocardial CS values were decreased in T1 compared with C1. With the exception of papillary epicardial CS, basal/papillary CS and LS of all 3 layers decreased in T2 compared with C2. Excepting papillary epicardial CS, all other values were decreased in T3 compared with C3.

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          Author and article information

          Journal
          Circ. J.
          Circulation journal : official journal of the Japanese Circulation Society
          Japanese Circulation Society
          1347-4820
          1346-9843
          May 25 2017
          : 81
          : 6
          Affiliations
          [1 ] Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine.
          [2 ] Department of Pediatric Cardiology, Sakakibara Heart Institute.
          [3 ] Department of Pediatric Cardiology, Tokyo Women's Medical University.
          [4 ] Department of Cardiovascular Surgery, Juntendo University Faculty of Medicine.
          Article
          10.1253/circj.CJ-16-1162
          28260735
          183155b7-3771-4c49-8125-0af0b883c43a
          History

          Echocardiography,Layer-specific strain,Myocardial deformation,Tetralogy of Fallot

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