12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      What does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder.

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The application of the concept and methods of brain oscillations has been an important research area in neurosciences. In the last decades, besides the application in cognitive processes, the study of changes in brain oscillations in diseases has also become an important focal point of research. In the present paper, some remarkable examples in three different diseases are taken into consideration: 1) schizophrenia (SZ), 2) Alzheimer's disease (AD), 3) bipolar disorders (BD). In the current literature, decreased oscillations in cortical recordings are observed in most of the pathologies. For example, decrease of gamma activity in SZ, decrease of delta activity in almost all diseases, as well as frequency shifts in alpha and the lower frequencies were recorded. However, there are also paradoxical cases in which an increase of oscillatory activities is observed. In BD, whereas alpha activity is greatly decreased, a huge increase of beta activity is observed. Or, in SZ, a paradoxical increase of gamma activity can be observed during cognitive loading. We also observed paradoxical changes in the analysis of connectivity. In AD, we find that alpha, delta, and theta coherences between distant parts of the cortex are greatly decreased, whereas in the gamma band, event-related coherences attain very high values. The comparison of the results and paradoxical changes in diseases may lead to important conclusions related to the web of oscillations and neurotransmitters. In turn, we could gain new insights to approach "brain function", in general.

          Related collections

          Author and article information

          Journal
          Int J Psychophysiol
          International journal of psychophysiology : official journal of the International Organization of Psychophysiology
          Elsevier BV
          1872-7697
          0167-8760
          May 2016
          : 103
          Affiliations
          [1 ] Istanbul Kultur University, Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul, Turkey. Electronic address: e.basar@iku.edu.tr.
          [2 ] Bremen University, Institute of Psychology and Cognition Research, Bremen, Germany.
          [3 ] Istanbul Kultur University, Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul, Turkey.
          [4 ] Dokuz Eylül University, Department of Neurosciences, Izmir, Turkey; Dokuz Eylül University, Department of Psychiatry, Izmir, Turkey.
          [5 ] Maltepe University, Department of Psychiatry, Istanbul, Turkey.
          [6 ] Dokuz Eylül University, Department of Neurosciences, Izmir, Turkey; Dokuz Eylül University, Department of Psychiatry, Izmir, Turkey; Dokuz Eylül University, Multidisciplinary Brain Dynamics Research Center, Izmir, Turkey.
          [7 ] Istanbul Kultur University, Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul, Turkey; Dokuz Eylül University, Department of Neurosciences, Izmir, Turkey; Dokuz Eylül University, Department of Psychiatry, Izmir, Turkey; Dokuz Eylül University, Multidisciplinary Brain Dynamics Research Center, Izmir, Turkey.
          Article
          S0167-8760(15)00034-3
          10.1016/j.ijpsycho.2015.02.004
          25660302
          1843f83a-4247-4c56-ab60-823f302ca1d5
          History

          Schizophrenia,Bipolar disorder,Connectivity,Oscillations,Alzheimer's disease

          Comments

          Comment on this article